Co-Amoxiclav KAPL Caution For Usage

Incompatibilities: To reconstitute 1.2-g vial, dissolve contents in 20 mL Water for Injection (final volume 20.9 mL). A transient pink coloration may appear during reconstitution. Reconstituted solutions are normally a pale, straw colour.
IV Injection: The stability of the solution is concentration-dependent, thus it should be used immediately upon reconstitution and given by slow IV injection over a period of 3-4 min. Co-Amoxiclav solutions should be used within 20 min of reconstitution. It may be injected directly into a vein or via a drip tube.
IV Infusion: Alternatively, Co-Amoxiclav may be infused in Water for Injection or 0.9% w/v Sodium Chloride IV Injection. Add, without delay⁺, 1.2 g reconstituted solution to 100 mL infusion fluid (e.g., using a mini-bag or in-line burette). Infuse over 30-40 min and complete within 4 hours of reconstitution.
⁺Solutions should be made up to full infusion volume immediately after reconstitution.
Any residual antibiotic solutions should be discarded.
Co-Amoxiclav should not be mixed with blood products, other proteinaceous fluids ie, protein hydrolysates or with IV lipid emulsions.
If Co-Amoxiclav is prescribed concurrently with an aminoglycoside, the antibiotics should not be mixed in the syringe, IV fluid container or given set because loss of activity of the aminoglycoside can occur under these conditions.